Try to disarm the intruder or kill him!

Try to disarm the intruder or kill him!

RNA interference and transgene-mediated cosuppression are trans-generational silencing mechanisms acting both at a post-transcriptional and epigenetic level. We have recently shown that both these procedures, which share several common factors and are commonly used to phenocopy gene deletions, also induce germ-line DNA damage and apoptosis. These observations shed new light on the cross-talk be...

DNA vaccines and apoptosis: to kill or not to kill?

The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 1 RNase. Proc. Natl. Acad. Sci. U. S. A. 100:4102-4107. 14. Shinkura, R., et al. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435–441. 15. Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E., and Lieber, M.R. 2003. R-loops at immunoglobulin class switch regions in the ch...

Do genes allow inflammation to kill or not to kill?

Acetylate to kill or save

Text by Nicole LeBrasseur [email protected] Acetylate to kill or save M ammalian p53 can kill, or it can save. The end result, according to Knights et al. (page 533), depends on opposing acetylation events that send p53 down disparate paths. The stabilization of p53 following cellular damage can trigger either apoptosis or a reversible cell cycle checkpoint that probably gives cells time ...

"and the Lord Sought to Kill Him" (exod 4:24): yet Once Again

The central question regarding the strange and mysterious incident of the encounter at the lodging place (Exod 4:24-26), the resolution of which determines our interpretation of the passage as a whole, is: who was subject to the deadly attack of God, Moses or Moses' (and Zipporah's) son? This paper argues that the redactor has structured the present narrative in which Exod 4:24-26 is embedded s...